Keerthi N, Iffath AI, Das A, Pathak S, Banerjee A. The role of Yamanaka factors in induced pluripotent stem cells and embryonic stem cell signaling. InStem Cells and Signaling Pathways 2024 Jan 1 (pp. 39-56). Academic Press. https://doi.org/10.1016/B978-0-443-18800-8.00021-6
Abstract
The advancements in stem cell research for reproductive and regenerative medicine have unraveled new junctures. Under suitable conditions, the stem cells can differentiate into an array of different cell types in in vitro and in vivo conditions. Induced pluripotent stem cells and embryonic stem cells are attractive resources for disease modeling and cell-based therapeutics in regenerative medicine because of their limitless pluripotency and capacity for self-renewal. Extrinsic signaling pathways and epigenetic, transcriptional, and posttranscriptional controls interact dynamically to regulate the special properties of stem cells. It is also widely known that the transcription factor Oct3/4 is necessary for the pluripotency of embryonic stem cells. In this chapter, we will go through the quick progress that has been achieved in locating and analyzing the intracellular signaling pathways that help explain how Yamanaka factors interact with induced pluripotent stem cells and embryonic stem cells.