Clinical trial in a dish using iPSCs shows lovastatin improves endothelial dysfunction and cellular cross-talk in LMNA cardiomyopathy

Authors: Nazish Sayed, Chun Liu, Mohamed Ameen, Farhan Himmati, Joe Z. Zhang, Saereh Khanamiri, Jan-Renier Moonen, Alexa Wnorowski, Linling Cheng, June-Wha Rhee, Sadhana Gaddam, Kevin C. Wang, Karim Sallam, Jack H. Boyd, Y. Joseph Woo, Marlene Rabinovitch, Joseph C. Wu

Published: 2020-07-29

DOI: 10.1126/scitranslmed.aax9276

Source: Full article

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Abstract

Patient-specific iPSCs model endothelial dysfunction in lamin A and C–related dilated cardiomyopathy and identify lovastatin as a therapy.