Deepika B, Gopikrishna A, Girigoswami A, Banu MN, Girigoswami K.
Current Pharmacology Reports. 2022 Jun;8(3):171-87. DOI: 10.1007/s40495-022-00284-x.
Abstract
Purpose of Review
Consistently, a huge number of surgeries are performed to supplant tissue which is damaged through infection or injury. The emerging field of tissue engineering aims to recover injured tissues by consolidating cells from the host body or donor’s body with exceptionally porous scaffold biomaterials that can act as a template for tissue recovery, to control the development of new tissue. Signals, cells, and scaffolds are triad components of tissue engineering that combine to produce functional tissue and organs.
Recent Findings
Pubmed and Google Scholar are the search engines used to sort out relevant papers on nanoscaffolds and their application in tissue engineering and regenerative medicine. Nanoscaffolding is known to be a clinical cycle used to regrow bone and tissue, including appendages and organs; likewise, it has been utilized to regrow the skin, but it has not been utilized yet for the development of complex organs like the heart etc. Different synthesis methods are being employed to engineer the scaffolds, such as electrospinning, layer-by-layer assembly, 3D printing, particle leaching etc. Natural bioscaffolds have also been used for growing cells and regenerative biology.
Summary
This article portrays the functional scaffolds used in different kinds of tissue engineering such as bone, liver, cartilage, vascular tissue, skin and cardiac tissue, etc., and an overview of various types of materials used in scaffolding for the tissue engineering applications and future aspects is discussed.