Authors: Linfeng Xu, Xiangpeng Li, Wenzong Li, Kai‐chun Chang, Hyunjun Yang, Nannan Tao, Pengfei Zhang, Emory M. Payne, Cyrus Modavi, Jacqueline Humphries, Chia‐Wei Lu, Adam R. Abate
Published: 2022-01-19
Source: Full article
AbstractPatterned surfaces can enhance the sensitivity of laser desorption ionization mass spectrometry by segregating and concentrating analytes, but their fabrication can be challenging. Here, a simple method to fabricate substrates patterned with micrometer‐scale wells that yield more accurate and sensitive mass spectrometry measurements compared to flat surfaces is described. The wells can also concentrate and localize cells and beads for cell‐based assays.