Generality-oriented optimization of enantioselective aminoxyl radical catalysis

Authors: Jonas Rein, Soren D. Rozema, Olivia C. Langner, Samson B. Zacate, Melissa A. Hardy, Juno C. Siu, Brandon Q. Mercado, Matthew S. Sigman, Scott J. Miller, Song Lin

Published: 2023-05-18

DOI: 10.1126/science.adf6177

Source: Full article

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Abstract

Catalytic enantioselective methods that are generally applicable to a broad range of substrates are rare. We report a strategy for the oxidative desymmetrization of