Pumping Iron: Ferritinophagy Promotes Survival and Therapy Resistance in Pancreatic Cancer

Authors: Vaibhav Jain, Ravi K. Amaravadi

Published: 2022-09-02

DOI: 10.1158/2159-8290.cd-22-0734

Source: Full article

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Abstract

Summary:Autophagy is an adaptive response to metabolic and therapeutic stress, especially in treatment-refractory cancers such as pancreatic cancer. In this issue of Cancer Discovery, two groups establish ferritinophagy, a selective autophagy program that could become a drug target, as the mechanism that pumps iron into mitochondria via the lysosome, enabling survival and therapy resistance in pancreas cancer.See related article by Santana-Codina et al., p. 2180 (3).See related article by Ravichandran et al., p. 2198 (4).