Authors: Ernesto H Pena Calderin, Jing-Juan Zheng, Nolan Boyd, Lindsey A McNally, Pawel Lorkiewicz, Bradford G Hill, Jason Hellmann
Published: 2023-06-15
DOI: 10.1161/circ.146.suppl_1.12910
Source: Full article
Emerging epidemiological data suggests that exercise imparts its CVD risk-reducing effects in part through improvements in systemic inflammation. The mechanisms underpinning the salutary effects of physical activity, however, remain incompletely understood. We recently reported that exercise enhances the production of specialized proresolving mediators (SPMs), which act as agonist of inflammation resolution through actions on macrophages (Mϕ). In this study, we find that wheel running accelerated the metabolism of proinflammatory lipid mediators LTB