Authors: Feng Tang, Xiaoping Wan, Dandan Yang, Ege Kacira, Xianyao xu, Neill Schwieterman, Daniela Ponce, Loren E Wold, Thomas Hund, Peter J Mohler, Isabelle Deschenes, Jidong A Fu
Published: 2023-06-15
DOI: 10.1161/circ.146.suppl_1.13309
Source: Full article
MicroRNAs (miRs) are involved in most biological events via a broadly-recognized RNA interference (RNAi) mechanism. miR1, encoded by miR1-1 and miR1-2 genes, is the predominant miRs of the heart and plays a critical role in heart development and cardiac diseases. Previous studies of miRs have focused on the canonical RNAi mechanism. Recently, we discovered a novel biophysical action of miR and found that miR1 physically binds to Kir2.1 and directly suppresses the inward rectifier potassium current (I