Abstract 14821: Effect of Single Volatile Organic Compound Metabolites and Volatile Organic Compound Mixtures on Vascular Function

Authors: Cameron Stopforth, Clara Sears, Justin Dials, Sanjay Srivastava, Aruni Bhatnagar, Rachel J Keith

Published: 2023-06-15

DOI: 10.1161/circ.146.suppl_1.14821

Source: Full article

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Abstract

Volatile organic compounds (VOCs) are ubiquitous environmental toxicants with pre-clinical evidence of decreased vascular health. Research to date has focused on single VOC metabolites and data is lacking on the effects on human vascular health. Many VOCs are strongly correlated with similar exposure sources. Though the compounding effects are poorly defined, they are likely to increase the overall toxicity. Therefore, we examined single VOC metabolites and mixtures’ association with flow mediated dilation (FMD), an index of vascular health.