Abstract 15339: Er-Resident S1pr1 in Lung Endothelium Regulates Innate Immune Function and Mediates Inflammatory Lung Injury

Authors: Mumtaz Anwar, Vijay Avin Balaji Ragunathrao, Mohammad Tauseef, Jagdish Chandra C Joshi, Rayees R Sheikh, Bhagwati Joshi, Yoshikazu Tsukasaki, Konstantinos Chronis, Dolly Mehta

Published: 2023-06-15

DOI: 10.1161/circ.146.suppl_1.15339

Source: Full article


Abstract

Endothelial-cell surface localized sphingosine 1 phosphate receptor 1 (S1PR1) is known to promote anti-inflammatory and barrier enhancing niche upon ligating S1P. Recently we showed that S1P and TNFα, later being a well-known inflammatory agonist, phosphorylate S1PR1 at tyrosine