Abstract 15637: Detection and Characterization of Fibrin/Amyloid Microclots in Patients With Post-Acute Sequelae of Covid-19

Authors: Melanie Walker, Emma M Federico, Douglas B Kell, Christopher Dupont, Amy Proal, Etheresia Pretorius

Published: 2023-06-15

DOI: 10.1161/circ.146.suppl_1.15637

Source: Full article

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Abstract

LongCovid or Post-Acute Sequelae of COVID-19 (PASC) is a diagnosis given to patients who experience a wide range of debilitating chronic symptoms after infection with SARS-CoV-2. The majority of individuals are PCR negative, indicating microbiological recovery. There are currently few LongCovid/PASC blood-based biomarkers. We used fluorescence microcopy to identify unique fibrin/amyloid micro-thrombosis and hyperactivated platelets in individuals with PASC. These fibrin/amyloid microclots may impede blood flow to tissue.