Authors: Ebuka I Onyenobi, Guanjie Chen, Ayo Doumatey, Ayotunde Famooto, Jie Zhou, Adebowale Adeyemo, Charles Rotimi, Clement Adebamowo, Sally Adebamowo
Published: 2023-03-14
DOI: 10.1161/circ.147.suppl_1.p391
Source: Full article
High blood pressure is a heritable risk factor for cardiovascular disease, stroke and other chronic conditions. There is an increasing prevalence of high blood pressure in sub-Saharan Africa. We aimed to identify genetic variants underlying blood pressure traits in Sub-Saharan Africa. We conducted a GWAS, meta-analyses and gene-set analyses of blood pressure traits (systolic, diastolic, pulse pressure), in African populations. We used the African Collaborative Center for Microbiome and Genomics Research data (ACCME, n=~15,000) for GWAS discovery and the Africa America Diabetes Mellitus study data (AADM, n=~5,200), for GWAS replication. Multiple SNPs were identified reaching genome-wide significance. The lead SNP from the elevated blood pressure group was on chromosome 16 (rs148403740, minor allelic frequency (MAF)=0.0176, p= 9.28x10