Small molecule modulation of protein polymerization

Authors: Eric S. Fischer, Lyn H. Jones

Published: 2022-03-10

DOI: 10.1039/d2cs00070a

Source: Full article


Abstract

Small molecules have been shown to not only mediate and enhance polymerization, in a manner analogous to a surface residue mutation or post-translational modification, but also bind and stabilize the repeating unit to inhibit self-assembly.