Mechanism and stereoselectivity in metal and enzyme catalyzed carbene insertion into X–H and C(sp<sup>2</sup>)–H bonds

Authors: Reena Balhara, Ritwika Chatterjee, Garima Jindal

Published: 2024-10-11

DOI: 10.1039/d4cs00742e

Source: Full article

Abstract

This review provides a mechanistic overview of asymmetric Fe, Cu, Pd, Rh, Au and heme-based enzymes catalyzed carbene insertion reactions to construct  C–X (X = O, N, S, etc.) and C–C bonds, focusing on the stereochemical models.