Authors: Fei Huang, Xiao Luo, Yang Ou, Zhaoxu Gao, Qiming Tang, Zhenzhen Chu, Xinguang Zhu, Yuehui He
Published: 2023-07-13
Source: Full article
Methylations on nucleosomal histones play fundamental roles in regulating eukaryotic transcription. Jumonji C domain–containing histone demethylases (JMJs) dynamically control the level of histone methylations. However, how JMJ activity is generally regulated is unknown. We found that the tricarboxylic acid cycle–associated enzyme α-ketoglutarate (α-KG) dehydrogenase (KGDH) entered the nucleus, where it interacted with various JMJs to regulate α-KG–dependent histone demethylations by JMJs, and thus controlled genome-wide gene expression in plants. We show that nuclear targeting is regulated by environmental signals and that KGDH is enriched at thousands of loci in