Authors: Kathleen E. Houlahan, Aziz Khan, Noah F. Greenwald, Cristina Sotomayor Vivas, Robert B. West, Michael Angelo, Christina Curtis
Published: 2024-05-30
Source: Full article
Tumors with the same diagnosis can have different molecular profiles and response to treatment. It remains unclear when and why these differences arise. Somatic genomic aberrations occur within the context of a highly variable germline genome. Interrogating 5870 breast cancer lesions, we demonstrated that germline-derived epitopes in recurrently amplified genes influence somatic evolution by mediating immunoediting. Individuals with a high germline-epitope burden in human epidermal growth factor receptor 2 (HER2/