Antibacterial activity of nonantibiotics is orthogonal to standard antibiotics

Authors: Mariana Noto Guillen, Carmen Li, Brittany Rosener, Amir Mitchell

Published: 2024-03-14

DOI: 10.1126/science.adk7368

Source: Full article


Abstract

Numerous nonantibiotic drugs have potent antibacterial activity and can adversely affect the human microbiome. The mechanistic underpinning of this toxicity remains largely unknown. We investigated the antibacterial activity of 200 drugs using genetic screens with thousands of barcoded