Cleavage-independent activation of ancient eukaryotic gasdermins and structural mechanisms

Authors: Yueyue Li, Yanjie Hou, Qi Sun, Huan Zeng, Fanyi Meng, Xiang Tian, Qun He, Feng Shao, Jingjin Ding

Published: 2024-04-25

DOI: 10.1126/science.adm9190

Source: Full article

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Abstract

Gasdermins (GSDMs) are pore-forming proteins that execute pyroptosis for immune defense. GSDMs are two-domain proteins activated by proteolytic removal of the inhibitory domain. In this work, we report two types of cleavage-independent GSDM activation. First,