Abstract 14275: Allosteric Inhibition Restricts Motion of the SMURF1 Glycine Hinge and Reverses Experimental Pulmonary Arterial Hypertension

Authors: Alex M Rothman, Amir Florentin, Catherine Quigley, Florence Zink, Olivier Bonneau, Rene Hemming, Amanda Hachey, Tomas Rejtar, Maulik Thaker, Rishi Jain, Ji-Hu Zhang, Simona Cotesta, Johannes Ottl, Alina Kordinsky, Reut Avishid, Thomas Troxler, Sarah K Binmahfooz, Nicholas W Morrell, Marc Humbert, Jennifer Cobb, Nils Osterman, John Tallerico, Duncan Shaw, Sabine Guth-Gundel, Gali Prag, David J Rowlands

Published: 2023-12-19

DOI: 10.1161/circ.148.suppl_1.14275

Source: Full article


Abstract

Background: