Compartmentalized dendritic plasticity during associative learning

Authors: Simon d’Aquin, Andras Szonyi, Mathias Mahn, Sabine Krabbe, Jan Gründemann, Andreas Lüthi

Published: 2022-04-14

DOI: 10.1126/science.abf7052

Source: Full article


Abstract

Experience-dependent changes in behavior are mediated by long-term functional modifications in brain circuits. Activity-dependent plasticity of synaptic input is a major underlying cellular process. Although we have a detailed understanding of synaptic and dendritic plasticity in vitro, little is known about the functional and plastic properties of active dendrites in behaving animals. Using deep brain two-photon Ca