Authors: Timofey A. Karginov, Antoine Ménoret, Nathan K. Leclair, Andrew G. Harrison, Karthik Chandiran, Jenny E. Suarez-Ramirez, Marina Yurieva, Keaton Karlinsey, Penghua Wang, Rachel J. O’Neill, Patrick A. Murphy, Adam J. Adler, Linda S. Cauley, Olga Anczuków, Beiyan Zhou, Anthony T. Vella
Published: 2024-09-12
Source: Full article
T cell receptor (TCR) sensitivity to peptide–major histocompatibility complex (MHC) dictates T cell fate. Canonical models of TCR sensitivity cannot be fully explained by transcriptional regulation. In this work, we identify a posttranscriptional regulatory mechanism of TCR sensitivity that guides alternative splicing of TCR signaling transcripts through an evolutionarily ultraconserved poison exon (PE) in the RNA-binding protein (RBP) TRA2β in mouse and human.