An injury-induced mesenchymal-epithelial cell niche coordinates regenerative responses in the lung

Authors: Dakota L. Jones, Michael P. Morley, Xinyuan Li, Yun Ying, Gan Zhao, Sarah E. Schaefer, Luis R. Rodriguez, Fabian L. Cardenas-Diaz, Shanru Li, Su Zhou, Ullas V. Chembazhi, Mijeong Kim, Chen Shen, Ana Nottingham, Susan M. Lin, Edward Cantu, Joshua M. Diamond, Maria C. Basil, Andrew E. Vaughan, Edward E. Morrisey

Published: 2024-12-12

DOI: 10.1126/science.ado5561

Source: Full article


Abstract

Severe lung injury causes airway basal stem cells to migrate and outcompete alveolar stem cells, resulting in dysplastic repair. We found that this “stem cell collision” generates an injury-induced tissue niche containing keratin 5