Axis formation in annual killifish: Nodal and β-catenin regulate morphogenesis without Huluwa prepatterning

Authors: Philip B. Abitua, Laura M. Stump, Deniz C. Aksel, Alexander F. Schier

Published: 2024-06-06

DOI: 10.1126/science.ado7604

Source: Full article

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Abstract

Axis formation in fish and amphibians typically begins with a prepattern of maternal gene products. Annual killifish embryogenesis, however, challenges prepatterning models as blastomeres disperse and then aggregate to form the germ layers and body axes. We show that