A tetramer of BCL11A is required for stable protein production and fetal hemoglobin silencing

Authors: Ge Zheng, Maolu Yin, Stuti Mehta, I-Te Chu, Stacy Wang, Alia AlShaye, Kirstin Drainville, Altantsetseg Buyanbat, Frédérique Bienfait, Karin Tenglin, Qian Zhu, Stuart H. Orkin

Published: 2024-11-28

DOI: 10.1126/science.adp3025

Source: Full article

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Abstract

Down-regulation of BCL11A protein reverses the fetal (HbF, α