High-resolution electron cryomicroscopy of V-ATPase in native synaptic vesicles

Authors: Claire E. Coupland, Ryan Karimi, Stephanie A. Bueler, Yingke Liang, Gautier M. Courbon, Justin M. Di Trani, Cassandra J. Wong, Rayan Saghian, Ji-Young Youn, Lu-Yang Wang, John L. Rubinstein

Published: 2024-06-20

DOI: 10.1126/science.adp5577

Source: Full article

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Abstract

Intercellular communication in the nervous system occurs through the release of neurotransmitters into the synaptic cleft between neurons. In the presynaptic neuron, the proton pumping vesicular- or vacuolar-type ATPase (V-ATPase) powers neurotransmitter loading into synaptic vesicles (SVs), with the V