Presence of Tertiary Lymphoid Structures and Exhausted Tissue-Resident T Cells Determines Clinical Response to PD-1 Blockade in Renal Cell Carcinoma

Authors: Miya B. Hugaboom, Lena V. Wirth, Kelly Street, Neil Ruthen, Opeyemi A. Jegede, Nicholas R. Schindler, Valisha Shah, Jacob P. Zaemes, Nourhan El Ahmar, Sayed Matar, Varunika Savla, Toni K. Choueiri, Thomas Denize, Destiny J. West, David F. McDermott, Elizabeth R. Plimack, Jeffrey A. Sosman, Naomi B. Haas, Mark N. Stein, Robert Alter, Mehmet A. Bilen, Michael E. Hurwitz, Hans Hammers, Sabina Signoretti, Michael B. Atkins, Catherine J. Wu, David A. Braun

Published: 2025-02-24

DOI: 10.1158/2159-8290.cd-24-0991

Source: Full article


Abstract

Abstract