Abstract 4141823: Deletion of Endothelial Neuropilin-1 Improves Cardiac Diastolic Function in Heart Failure with Preserved Ejection Fraction

Authors: Yu Huo, Sarah Chau, Enfeng Wang, Ahmed Fayyaz, Debabrata Mukhopadhyay, Margaret Redfield, Ying Wang

Published: 2024-11-14

DOI: 10.1161/circ.150.suppl_1.4141823

Source: Full article

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Abstract

Heart failure with preserved ejection fraction (HFpEF), characterized by cardiac diastolic dysfunction, leads to premature mortality with limited effective treatments. A recent study in HFpEF patients suggested neuropilin 1 (NRP1), an endothelial cell (EC) originated prognostic marker, might contribute to the pathogenesis of HFpEF. However, the functional role of NRP1 in the pathogenesis of HFpEF remains unclear.