Authors: Julian Wagner, Kathrin Stilz, Lukas Tombor, David Rodriguez Morales, Simone-franziska Glaser, Ariane Fischer, Katja Schmitz, Michail Yekelchyk, Thomas Braun, Andreas Zeiher, Stefanie Dimmeler
Published: 2024-11-14
DOI: 10.1161/circ.150.suppl_1.4143675
Source: Full article
Aging is a major risk factor for cardiovascular diseases contributing to the progressive deterioration of heart function. Since the vascular niche was shown to maintain cardiac homeostasis, we explored the epigenomic and transcriptional circuits driving endothelial cell (EC) impairment with aging. Analysis of chromatin accessibility by snATAC-seq and gene expression by RNA-seq of hearts from 18- to 20-month-old mice revealed a significant reduction in chromatin accessibility and expression of the zinc finger transcription factor ZBTB16, which was also confirmed in aged human hearts. Haploinsufficiency of