Abstract 4147602: The Paradox Role of Sirtuin 6 In Coronary Microvascular Function under Metabolic Stress

Authors: Yang Wang, Molly Enrick, James Gadd, Blessing Nagy, Iyanuoluwa Ogunmiluyi, Liya Yin

Published: 2024-11-11

DOI: 10.1161/circ.150.suppl_1.4147602

Source: Full article


Abstract

Coronary microvascular dysfunction (CMD), which is associated with diabetic cardiomyopathy, Takotsubo cardiomyopathy, andheart failure with preserved ejection fraction (HFpEF), is understudied. CMD is characterized by impaired endothelial-dependent vasodilation, but detailed mechanisms have yet to be elucidated.