Abstract 4147923: Role of Adipocyte Circadian Rhythm in the Exacerbation of Diabetic Ischemic Heart injury

Authors: Huilan Tan, Yalin Wu, Jianli Zhao, Taslima Akter Shila, yanwen liu, John Zhang, Kayleigh Wyatt, Amr Mahmoud, Xinliang-Xin Ma, Martin E Young, Yajing Wang

Published: 2024-11-14

DOI: 10.1161/circ.150.suppl_1.4147923

Source: Full article


Abstract

Diabetes worsens myocardial infarction (MI) pathologic progress, termed diabetic exacerbation of ischemic heart failure (IHF), with mechanisms and effective therapies remaining poorly understood. Circadian rhythm (CR) disruption is associated with heart failure, but its impact on diabetic IHF has not been studied. Adipocytes involve in maintaining physiological homeostasis and exhibit diurnal oscillations. However, the effects of circadian rhythm disruption on adipocyte dysfunction and diabetic IHF are unclear.