Reactivation of Oxidized Soluble Guanylate Cyclase as a Novel Treatment Strategy to Slow Progression of Calcific Aortic Valve Stenosis: Preclinical and Randomized Clinical Trials to Assess Safety and Efficacy

Authors: Bin Zhang, Maurice Enriquez-Sarano, Hartzell V. Schaff, Hector I. Michelena, Carolyn M. Roos, Michael A. Hagler, Heyu Zhang, Grace Casaclang-Verzosa, Runqing Huang, Anna Bartoo, Sushant Ranadive, Michael J. Joyner, Sorin Pislaru, Vuyisile T. Nkomo, Walter K. Kremers, Philip A. Araoz, Gurpreet Singh, Michael A. Walters, Jon Hawkinson, Kevin Y. Cunningham, Jaeyun Sung, Brandon Dunagan, Zi Ye, Jordan D. Miller

Published: 2025-02-24

DOI: 10.1161/circulationaha.123.066523

Source: Full article

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Abstract

BACKGROUND: