Inositol 1,4,5-Trisphosphate Receptor 1 Gain-of-Function Increases the Risk for Cardiac Arrhythmias in Mice and Humans

Authors: Bo Sun, Mingke Ni, Yanhui Li, Zhenpeng Song, Hui Wang, Hai-Lei Zhu, Jinhong Wei, Darrell Belke, Shitian Cai, Wenting Guo, Jinjing Yao, Shanshan Tian, John Paul Estillore, Ruiwu Wang, Mads Toft Søndergaard, Malene Brohus, Palle Duun Rohde, Yongxin Mu, Alexander Vallmitjana, Raul Benitez, Leif Hove-Madsen, Michael Toft Overgaard, Glenn I. Fishman, Ju Chen, Shubhayan Sanatani, Arthur A.M. Wilde, Michael Fill, Josefina Ramos-Franco, Mette Nyegaard, S.R. Wayne Chen

Published: 2024-12-10

DOI: 10.1161/circulationaha.124.070563

Source: Full article


Abstract

BACKGROUND: