IL-4 mediated TAP2 downregulation is a dominant and reversible mechanism of immune evasion and immunotherapy resistance in non-small cell lung cancer

Authors: Kishu Ranjan, Barani Kumar Rajendran, Imad Ud Deen, Adrien Costantini, Miguel Lopez de Rodas, Shruti S. Desai, Frankie Scallo, Nicole Gianino, Soldano Ferrone, Kurt A. Schalper

Published: 2025-03-17

DOI: 10.1186/s12943-025-02276-z

Source: Full article

IL-4 mediated TAP2 downregulation is a dominant and reversible mechanism of immune evasion and immunotherapy resistance in non-small cell lung cancer

Abstract