Lenvatinib Plus Pembrolizumab and Chemotherapy Versus Chemotherapy in Advanced Metastatic Gastroesophageal Adenocarcinoma: The Phase III, Randomized LEAP-015 Study

Authors: Kohei Shitara, Sylvie Lorenzen, Jin Li, Yuxian Bai, Manuel González Fernández, Mynor Aguilar, Hirokazu Shoji, Felipe Reyes-Cosmelli, Yovany Rodriguez Peña, Luis Corrales, Lucjan Wyrwicz, Daniel Acosta Eyzaguirre, Yueyin Pan, Min-Hee Ryu, Deirdre J. Cohen, Zev A. Wainberg, Geoffrey Ku, Josep Tabernero, Eric Van Cutsem, Shu-Kui Qin, Do-Youn Oh, Jianming Xu, Li Wen Liang, Sonal Bordia, Pooja Bhagia, Sun Young Rha, , Ezequiel Heman Slutsky, Juan Cundom, Andrea Gabriela Soria, Marcela Alejandro Carballido, Juan Manuel O'Connor, Julieta Grasseli, Matthew Burge, Daniel Paul Brungs, Muhammad Adnan Khattak, Karen Paula Jozefa Geboes, Eric Van Cutsem, Jeroen Dekervel, Lionel D. Hondt, Frederic Lemay, Rosalyn Anne Juergens, Felipe Reyes, Gonzalo Pizarro Brito, Maria Alejandra Ojeda, Herman Adolfo Araya, Patricio Eduardo Yanez, Jianwei Yang, Xi Chen, Yuxian Bai, Hongming Pan, Nong Xu, Yueyin Pan, Qinghong Guo, Baorui Liu, Feng Ye, Xin Wang, Qi Li, Yong Tang, Huiting Xu, Haichuan Su, Ying Cheng, Xianli Yin, Qun Zhao, Ning Li, Jun You, Yi Ba, Jinsheng We, Lin Shen, Jin Li, Wangjun Liao, Zhen Li, Lei Yang, Yovany Eduardo Rodriguez Pena, Ivan Jose Bustillo, Carlos Jose Narvaez, Manuel Enrique Gonzalez Fernandez, Raimundo Manneh, Andres Fernando Arenas Arias, Luis Corrales, Andres Wiernik Rodriguez, Thomas Aparicio, Yuan Touchefeu, Helene Boussion-Desloges, Laurent Mineur, Christophe Tournigand, Francois Ghiringhelli, Marie Pierre Galais, Eric Terrebonne, Thomas Walter, Mathieu Baconnier, Sylvie Lorenzen, Eray Goekkurt, Annika Kurreck, Arne Kandulski, Thorsten Goetze, Florian Lordick, Mynor Aguilar, Karla Alejandra Lopez, Rixci Augusto Lenin Ramirez Fallas, Pier Anyelo Ramos Elias, Juan Pablo Moreira, Wing Lok Wendy Chan, Ashely Cheng, Winnie Yeo, Maeve Lowery, Adrian Murphy, Sharon Pelles Avraham, Ayala Hubert, Irit Ben-Aharon, Valeriya Semenisty, Gali Perl, Wael Hozaeel, Armando Santoro, Elena Aurelia Mazza, Ferdinando de Vita, Guiseppe Aprile, Giovanni Gerardo Cardellino, Filippo Pietrantonio, Pierfrancesco Tassone, Kohei Shitara, Hirokazu Shoji, Yukiya Narita, Hiroki Hara, Kensei Yamaguchi, Naotoshi Sugimoto, Nozomu Machida, Tomohiro Nishina, Akihito Tsuji, Yasuhiro Choda, Kenji Amagai, Masahiro Tsuda, Shogen Boku, Boguslawa Karaszewska, Kamil Stanislaw Kuc, Jacek Mackiewicz, Lucjan Stanislaw Wyrwicz, Lukasz Hajac, Alexy Alexandrovich Tryakin, Dmitry Aleksandrovich Nosov, Rashida Orlova, Alexey Mikhailovich Karachun, Michael Osipov, Mikhail Valerievich Kopp, Natalia Vladimirovna Fadeeva, Nikolay Viktorovich Kislov, Sun Young Rha, Seung Tae Kim, Min-Hee Ryu, Do-Youn Oh, Keun-Wook Lee, Hei-Cheul Jeung, Jonggwon Choi, Sang Cheul Oh, Paula Jimenez Fonseca, Fernando Rivera Herrero, Pilar Aitana Calvo Ferrandiz, Daniel Acosta Eyzaguirre, Kun-Huei Yeh, Jen-Shi Chen, Li-Yuan Bai, Chia-Jui Yen, Bulent Erdogan, Pinar Gursoy, Mustafa Ozguroglu, Suayib Yalcin, Umut Demirci, Mehmet Bilici, Ilhan Hacibekiroglu, Hugo Ford, Kai-Keen Shiu, Martin Scott-Brown, Russell Petty, Wasat Mansoor, Zev A. Wainberg, Marcus Noel, Peter Enzinger, Sreenivasa Chandana, Geoffrey Ku, Dierdre Cohen, Vincent Lam

Published: 2025-05-31

DOI: 10.1200/jco-25-00748

Source: Full article


Abstract

PURPOSE