A phase 1 study of intracerebroventricular (ICV) delivery of bivalent chimeric antigen receptor (CAR) T-cells targeting EGFR and IL13Ra2 in patients with recurrent glioblastoma (rGBM).

Authors: Stephen Joseph Bagley, Zev A. Binder, Joseph A. Fraietta, Arati Suvas Desai, Ali Nabavizadeh, Amy Marshall, Rachel M. Leskowitz, Vanessa E. Gonzalez, Whitney Gladney, David Barrett, Dana Silverbush, Nelson Freeburg, Daniel Chafamo, Gayathri Konanur, MacLean Nasrallah, Wei-Ting Hwang, Donald L. Siegel, Carl H. June, Elizabeth O. Hexner, Donald O'Rourke

Published: 2025-05-28

DOI: 10.1200/jco.2025.43.16_suppl.102

Source: Full article

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Abstract

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