Intratumoral activation of the necroptotic pathway components RIPK1 and RIPK3 potentiates antitumor immunity

Authors: Annelise G. Snyder, Nicholas W. Hubbard, Michelle N. Messmer, Sigal B. Kofman, Cassidy E. Hagan, Susana L. Orozco, Kristy Chiang, Brian P. Daniels, David Baker, Andrew Oberst

Published: 2019-06-21

DOI: 10.1126/sciimmunol.aaw2004

Source: Full article

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Abstract

Activation of the necroptotic kinases RIPK1 and RIPK3 within the tumor microenvironment enhances immune-mediated tumor control.