Origins and clonal convergence of gastrointestinal IgE

Authors: Ramona A. Hoh, Shilpa A. Joshi, Ji-Yeun Lee, Brock A. Martin, Sushama Varma, Shirley Kwok, Sandra C. A. Nielsen, Parastu Nejad, Emily Haraguchi, Priya S. Dixit, Swetha V. Shutthanandan, Krishna M. Roskin, Wenming Zhang, Dana Tupa, Bryan J. Bunning, Monali Manohar, Robert Tibshirani, Nielsen Q. Fernandez-Becker, Neeraja Kambham, Robert B. West, Robert G. Hamilton, Mindy Tsai, Stephen J. Galli, Rebecca S. Chinthrajah, Kari C. Nadeau, Scott D. Boyd

Published: 2020-03-06

DOI: 10.1126/sciimmunol.aay4209

Source: Full article


Abstract

Peanut-allergic patient GI tissues implicate local IgE class-switching and common IgH genetic rearrangements in pathogenesis.