Authors: Zdravka Daneva, Yen Lin Chen, Matteo Ottolini, Brant E Isakson, Swapnil K Sonkusare
Published: 2022-03-19
DOI: 10.1161/circ.144.suppl_1.10294
Source: Full article
The pulmonary endothelial cells (EC) dilate small pulmonary arteries (PAs) and maintain low pulmonary arterial pressure (PAP). Importantly, the loss of EC function contributes to elevated PAP in pulmonary hypertension (PH). Recent studies show that Pannexin 1 (Panx1), an ATP efflux pathway at the cell membrane, is a critical regulator of endothelial function. However, the impact of endothelial Panx1 (Panx1