Authors: Sarah-eve Lemay, Mónica S Montesinos, Yann Grobs, Tsukasa Shimauchi, Sandra Breuils Bonnet, Sandra Martineau, Xinqiang Huang, James E Dowling, Min Lu, Adrian S Ray, Roxane Paulin, François Potus, Steeve Provencher, Olivier BOUCHERAT, Sebastien Bonnet
Published: 2022-03-19
DOI: 10.1161/circ.144.suppl_1.10717
Source: Full article
Pulmonary arterial hypertension (PAH) is characterized by progressive obstruction and decreased compliance of pulmonary arteries (PA), leading to right ventricular (RV) failure and premature death. It is now recognized that, like cancer cells, PA smooth muscle cells (PASMCs) exhibit exaggerated proliferation and resistance to apoptosis in response to increased PA stiffness caused by extracellular matrix (ECM) remodeling. Integrins (members of the cell adhesion receptors superfamily) are known to promote cell proliferation, survival, hypertrophic growth and fibrosis, which are key elements in the progression of PAH. Therefore, we explored integrins expression and its effects on PA remodeling and RV failure.