Abstract 108: Reactivation of Myc Transcription in the Heart Unlocks its Proliferative Capacity

Authors: Catherine H Wilson, Megan J Bywater, Deborah L Burkhart, Arianna Sabò, Jasmin Straube, Vera Pendino, James E Hudson, Gregory A Quaife-Ryan, Enzo R Porrello, Theresia R Kress, Bruno Amati, Trevor D Littlewood, Gerard I Evan

Published: 2019-10-16

DOI: 10.1161/res.125.suppl_1.108

Source: Full article


Abstract

It is unclear why some tissues are refractory to the mitogenic effects of the pleiotropic transcription factor Myc, even when its expression is deregulated. We have developed an