Authors: Mei Methawasin, Josh Strom, Zaynab Hourani, John E Smith, Henk L Granzier
Published: 2019-10-16
DOI: 10.1161/res.125.suppl_1.336
Source: Full article
Low myocardial cGMP-PKG activity is associated with increased cardiomyocyte stiffness in HFpEF. cGMP is mainly hydrolyzed by PDE (phosphodiesterases)5a and PDE9a. Importantly, PDE9a protein expression was reported to be upregulated in human HFpEF myocardium and chronic administration of PDE9a inhibitor reversed pre-established cardiac hypertrophy and systolic dysfunction in mice subjected to TAC (Transverse Aortic Constriction).