Authors: Emma K Murray, Alyssa A Lombardi, Jonathan P Lambert, John W Elrod
Published: 2019-10-16
DOI: 10.1161/res.125.suppl_1.737
Source: Full article
Necrotic cell death is the main way in which cells die during myocardial infarction (MI) and heart failure (HF), yet the molecular mechanisms regulating necrotic cell death are poorly defined. To elucidate the key regulators of plasma membrane rupture during necrotic cell death a genome-wide shRNA loss-of-function screen was performed which identified components of SNARE-mediated membrane fusion as potential facilitators of Ca