Authors: Claire L Curl, Antonia J Raaijmakers, James R Bell, Tristan W Harding, Stephen B Harrap, Lea M Delbridge
Published: 2019-10-16
DOI: 10.1161/res.125.suppl_1.765
Source: Full article
Heart failure with preserved ejection fraction (HFpEF) accounts for >50% of heart failure patients and is particularly prevalent in women. A mechanistic understanding of the intrinsic cardiomyocyte pathology in HFpEF is limited with no selective treatments identified. Gender-specific aspects of HFpEF etiology have not been well characterized. The aim of this study was to experimentally evaluate sex difference in cardiac and cardiomyocyte performance in HFpEF, using a novel recently developed rodent model of HFpEF - the ‘Hypertrophic Heart Rat’.