Authors: Marcus Henze, Weikang Ma, Fiona Wong, Henry Gong, Robert Anderson, Carlos del Rio, Thomas C Irving
Published: 2019-10-16
DOI: 10.1161/res.125.suppl_1.905
Source: Full article
Length dependent activation (LDA) is a property of muscle where increased sarcomere length (SL) leads to increased force of contraction. Despite its key role in both normal and pathological states, the molecular mechanisms underlying LDA are not understood. Previous studies suggest that increased titin-based passive tension at longer SL triggers structural changes in the troponin complex leading to increased Ca