Abstract 9924: Polygenic Risk Score for PR Interval is Associated with Increased Risk of Ischemic Stroke

Authors: Huichun Xu, John W Cole, Brady Gaynor, Kathy Ryan, Braxton D Mitchell, Tatjana Rundek, Bradford B Worrall, Patrick T Ellinor, Diane Fatkin, Steven A Lubitz, Gui Pare, Dana Leifer

Published: 2024-04-23

DOI: 10.1161/circ.144.suppl_1.9924

Source: Full article

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Abstract

Atrial cardiomyopathy (AC) is an emerging risk factor for ischemic stroke (IS). We used polygenic risk scores (PRS) to study the association of the PR interval (PRI)-- an ECG marker for AC-- with IS and IS subtypes. We studied PRI, rather than other AC traits, because a validated multi-ethnic PRI-PRS exists.