Targeting Piezo1 unleashes innate immunity against cancer and infectious disease

Authors: Berk Aykut, Ruonan Chen, Jacqueline I. Kim, Dongling Wu, Sorin A. A. Shadaloey, Raquel Abengozar, Pamela Preiss, Anjana Saxena, Smruti Pushalkar, Joshua Leinwand, Brian Diskin, Wei Wang, Gregor Werba, Matthew Berman, Steve Ki Buom Lee, Alireza Khodadadi-Jamayran, Deepak Saxena, William A. Coetzee, George Miller

Published: 2020-08-21

DOI: 10.1126/sciimmunol.abb5168

Source: Full article


Abstract

Blockade of the Piezo1 mechanoreceptor decreases myeloid cell suppression of immune responses to cancer and polymicrobial sepsis.