Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients

Authors: Anita S. Iyer, Forrest K. Jones, Ariana Nodoushani, Meagan Kelly, Margaret Becker, Damien Slater, Rachel Mills, Erica Teng, Mohammad Kamruzzaman, Wilfredo F. Garcia-Beltran, Michael Astudillo, Diane Yang, Tyler E. Miller, Elizabeth Oliver, Stephanie Fischinger, Caroline Atyeo, A. John Iafrate, Stephen B. Calderwood, Stephen A. Lauer, Jingyou Yu, Zhenfeng Li, Jared Feldman, Blake M. Hauser, Timothy M. Caradonna, John A. Branda, Sarah E. Turbett, Regina C. LaRocque, Guillaume Mellon, Dan H. Barouch, Aaron G. Schmidt, Andrew S. Azman, Galit Alter, Edward T Ryan, Jason B. Harris, Richelle C. Charles

Published: 2020-10-08

DOI: 10.1126/sciimmunol.abe0367

Source: Full article


Abstract

IgM and IgA responses to SARS-CoV-2 RBD in severe COVID patients decay rapidly, while IgG responses persist for over 3 months.