Cutaneous innate immune tolerance is mediated by epigenetic control of MAP2K3 by HDAC8/9

Authors: Yu Sawada, Teruaki Nakatsuji, Tatsuya Dokoshi, Nikhil Nitin Kulkarni, Marc C. Liggins, George Sen, Richard L. Gallo

Published: 2021-05-21

DOI: 10.1126/sciimmunol.abe1935

Source: Full article

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Abstract

Inhibition of HDAC8 and HDAC9 impairs keratinocyte tolerance of TLR ligand stimulation, leading to cutaneous inflammation.