Authors: Giulia Torrieri, Mónica P Ferreira, Mohammad-Ali Shahbazi, Virpi Talman, Cláudia Carvalho, Tuuli Karhu, João F Pinto, Jouni Hirvonen, Heikki J Ruskoaho, Vimalkumar Balasubramanian, Hélder A Santos
Published: 2020-10-27
DOI: 10.1161/res.127.suppl_1.221
Source: Full article
The advance of nanomedicines has recently offered novel approaches to tackle cardiovascular diseases and, in particular, myocardial infarction (MI). However, the constant pumping of the heart and the still poor knowledge of targetable moieties, prevented the application of nanomedicines in the cardiovascular field to rise. Tannic acid, a polyphenol derived from plants, has showed affinity for components of the extracellular matrix, in particular elastin, allowing the retention of protein aggregates in the cardiac tissue. Here, we explored the heart targeting abilities of tannic acid by using it to coat spermine modified-acetalated dextran (AcDXSp) nanoparticles (NPs). Briefly, particles were prepared by single emulsion technique and then coated with tannic acid by complexation of the polyphenol with Fe