Authors: Xinrui Wang, Tina C Wan, Amelia Lauth, Michaela Patterson, John W Lough, John A Auchampach
Published: 2020-10-27
DOI: 10.1161/res.127.suppl_1.399
Source: Full article
Cardiac disease and injury are accompanied by significant cardiomyocyte (CM) loss. CMs are essentially non-regenerable, preventing re-muscularization and resulting in permanent dysfunction during the healing process. The identification of factors from multiple layers of inhibitors that induce and maintain CM’s pronounced state of proliferative senescence provides potential therapeutic targets. Tip60 (